Adaptation and Radiation-Induced Chromosomal Instability Studied by Statistical Modeling~!2009-12-10~!2010-02-20~!2010-03-30~!
نویسندگان
چکیده
منابع مشابه
Chromosomal instability in unirradiated hemaopoietic cells induced by macrophages exposed in vivo to ionizing radiation.
The tumorigenic potential of ionizing radiation has conventionally been attributed to DNA damage in irradiated cells induced at the time of exposure. Recently, there have been an increasing number of reports of damage in unirradiated cells that are either neighbors or descendants of irradiated cells, respectively, regarded as bystander effects and genomic instability and collectively termed non...
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Using a bone marrow transplantation protocol in which we transplanted a mixture of irradiated and nonirradiated bone marrow cells that were distinguishable by a cytogenetic marker, we have demonstrated chromosomal instability in the progeny of nonirradiated hemopoietic stem cells. This first demonstration of a link between a bystander effect of ionizing radiation and the induction of genomic in...
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Genomic instability is characterized by the increased rate of acquisition of alterations in the mammalian genome. These changes encompass a diverse set of biological end points including karyotypic abnormalities, gene mutation and amplification, cellular transformation, clonal heterogeneity and delayed reproductive cell death. The loss of stability of the genome is becoming accepted as one of t...
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We report on a current investigation of the anisotropy pattern induced by cosmic strings on the cosmic microwave background radiation (MBR). We have numerically evolved a network of cosmic strings from a redshift of Z = 100 to the present and calculated the anisotropies which they induce. Based on a limited number of realizations, we have compared the results of our simulations with the observa...
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Although it is well established that ionizing radiation and benzene are epidemiologically linked to acute myeloid leukemia (AML), the underlying mechanisms are not understood. We have shown that gamma-radiation can induce a persisting genomic instability in the clonal descendants of hemopoietic stem cells manifested as a high frequency of nonclonal chromosome and chromatid aberrations. A striki...
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ژورنال
عنوان ژورنال: The Open Evolution Journal
سال: 2010
ISSN: 1874-4044
DOI: 10.2174/1874404401004010001